From Bob Powitz, via Bill Anderson of the University of Waterloo:
Nanoplastics linked to heart attack, stroke and early death, study finds
https://www.cnn.com/2024/03/06/health/nanoplastics-heart-attack-study-wellness/index.html
"People with microplastics or nanoplastics in their carotid artery tissues were twice as likely to have a heart attack, stroke or die from any cause over the next three years than people who had none, a new study found. Carotid arteries, which lie on each side of the neck and carry blood to the brain, can become clogged with fatty cholesterol plaques in a similar fashion as the arteries leading into the heart, a process known as atherosclerosis." "To date, our study is the first that associated the plastic contamination with human diseases," said Raffaele Marfella, lead author of the study published Wednesday in the New England Journal of Medicine.
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Here's the paper:
Microplastics and Nanoplastics in Atheromas and Cardiovascular Events
https://www.nejm.org/doi/full/10.1056/NEJMoa2309822
March 7, 2024
N Engl J Med 2024; 390:900-910
DOI: 10.1056/NEJMoa2309822
Abstract
"BACKGROUND
Microplastics and nanoplastics (MNPs) are emerging as a potential risk factor for cardiovascular disease in preclinical studies. Direct evidence that this risk extends to humans is lacking.
METHODS
We conducted a prospective, multicenter, observational study involving patients who were undergoing carotid endarterectomy for asymptomatic carotid artery disease. The excised carotid plaque specimens were analyzed for the presence of MNPs with the use of pyrolysis–gas chromatography–mass spectrometry, stable isotope analysis, and electron microscopy. Inflammatory biomarkers were assessed with enzyme-linked immunosorbent assay and immunohistochemical assay. The primary end point was a composite of myocardial infarction, stroke, or death from any cause among patients who had evidence of MNPs in plaque as compared with patients with plaque that showed no evidence of MNPs.
RESULTS
A total of 304 patients were enrolled in the study, and 257 completed a mean (±SD) follow-up of 33.7±6.9 months. Polyethylene was detected in carotid artery plaque of 150 patients (58.4%), with a mean level of 21.7±24.5 μg per milligram of plaque; 31 patients (12.1%) also had measurable amounts of polyvinyl chloride, with a mean level of 5.2±2.4 μg per milligram of plaque. Electron microscopy revealed visible, jagged-edged foreign particles among plaque macrophages and scattered in the external debris. Radiographic examination showed that some of these particles included chlorine. Patients in whom MNPs were detected within the atheroma were at higher risk for a primary end-point event than those in whom these substances were not detected (hazard ratio, 4.53; 95% confidence interval, 2.00 to 10.27; P<0.001).
CONCLUSIONS
In this study, patients with carotid artery plaque in which MNPs were detected had a higher risk of a composite of myocardial infarction, stroke, or death from any cause at 34 months of follow-up than those in whom MNPs were not detected."
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Monica Milla
Standards Lead
NSF
(734) 214-6223
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