Proposed revisions to NSF/ANSI/CAN 600 – Health Effects Evaluation and Criteria for Chemicals in Drinking Water (600i7r1).
This ballot includes the following proposed revisions to NSF/ANSI/CAN 600:
— Updates to definitions acute exposure, benchmark dose modeling, the cancer slope factor, human equivalent dose, short-term exposure level, target substance, toxicodynamics and weight of evidence;
— Definitions were added for CBEL, quantitative structure activity relationship and structure activity relationship;
— Updates to the quality assessment of study review in 3.3.1;
— Updates to study durations of exposure to be consistent throughout section 3;
— Refinement for study requirements in Tables 3.1 and 3.2;
— Updated text for the benchmark dose modeling approach in Section 3.6.3.1.3;
— Updates to the uncertainty factor selection including the addition of key questions to Table 3.4;
— Updates to Table 3.5 regarding lifestage adjustment based on the revised Exposure Factors Handbook for drinking water ingestion;
— Removal of Table 3.6 and additional guidance associated with review of authority documents;
— Movement of section Tables to within the section as opposed to the end of the document for better readability;
— Initiative to update the STEL guidance was completed and is reflected in the revised NSF/ANSI/CAN 600 that includes study and uncertainty factor selection guidance; and
— Key Table 4.1 Updates |
